Brain Imaging Methods in Lifespan Psychology

Research on human development seeks to delineate the variable and invariant properties of age-graded changes in the organization of brain–behavior–environment systems. Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) have become indispensable tools for the noninvasive assessment of brain function, anatomy, microstructure, and metabolism. This project seeks to ascertain and improve the measurement quality of standard brain imaging protocols and to complement the standard repertoire by additional methods that carry promise for understanding the ways in which brains change as a function of maturation, learning, and senescence.

Central questions in lifespan psychology often are about the range and direction of change and variability, be it longitudinal change observed over years and decades, intervention-induced change over weeks and months, or fluctuations that occur from day to day and from moment to moment. Random measurement error and systematic drifts can compromise the reliable measurement of change. Hence, the project takes a special interest in exploring, safeguarding, and improving the precision and temporal stability of measurement.

The Max Planck Institute for Human Development has a magnetic resonance imaging scanner (Siemens TIM-Trio with a field strength of 3 Tesla). It is used to measure the structure and function of the brain. more

Selected Publications until 2023

Polk, S. E., Kleemeyer, M. M., Köhncke, Y., Brandmaier, A. M., Bodammer, N. C., Misgeld, C., Porst, J., Wolfarth, B., Kühn, S., Lindenberger, U., Wenger, E., & Düzel, S. (2022). Change in latent gray matter structural integrity is associated with change in cardiovascular fitness in older adults who engage in at-home aerobic exercise. Frontiers in Human Neuroscience, 16, Article 852737.
Wenger, E., Polk, S. E., Kleemeyer, M. M., Weiskopf, N., Bodammer, N. C., Lindenberger, U., & Brandmaier, A. M. (2022). Reliability of quantitative multiparameter maps is high for magnetization transfer and proton density but attenuated for R1 and R2* in healthy young adults. Human Brain Mapping, 43(11), 3585–3603.
Mårtensson, J., Eriksson, J., Bodammer, N. C., Lindgren, M., Johansson, M., Nyberg, L., & Lövdén, M. (2020). White matter microstructure predicts foreign language learning in army interpreters. Bilingualism: Language and Cognition, 23, 763–771.
Dahl, M. J., Mather, M., Düzel, S., Bodammer, N. C., Lindenberger, U., Kühn, S., & Werkle-Bergner, M. (2019). Rostral locus coeruleus integrity is associated with better memory performance in older adults. Nature Human Behaviour, 3, 1203–1214.
Bender, A. R., Keresztes, A., Bodammer, N. C., Shing, Y. L., Werkle-Bergner, M., Daugherty, A. M., Yu, Q., Kühn, S., Lindenberger, U., & Raz, N. (2018). Optimization and validation of automated hippocampal subfield segmentation across the lifespan. Human Brain Mapping, 39(2), 916–931.
Brandmaier, A. M., Wenger, E., Bodammer, N. C., Kühn, S., Raz, N., & Lindenberger, U. (2018). Assessing reliability in neuroimaging research through intra-class effect decomposition (ICED). eLife, 7, Article e35718.

Project Master Theses

Maximilian Michael Wichmann (Medizinphysik, Technische Universität Dortmund):
Reliability of Principal Fibre Tract Orientation Using Different High Angular Resolution Diffusion Imaging Methods

Paul Enggruber & Felix Kreis (Physik, Technische Universität Berlin):
Development of Three-Dimensional Spectrally Selective Phosphorus Magnetic Resonance Imaging for Analysing Metabolism in the Human Brain

Tian Yang (Medizintechnik, Technische Universität Berlin):
Measurement of Image Artifacts in Simultaneous Application of Transcranial Magnetic Stimulation (TMS) and Functional Magnetic Resonance Imaging (fMRI)

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