Phosphorus MRS

The mitochondria are organelles in eukaryotic cells that provide energy for the cell's metabolism through glycolysis (i.e., the releasing of energy stored in glucose). Adenosine triphosphate (ATP) is generated during glycolysis for high-energy short-time storage. ATP concentration levels are stabilized by the creatine kinase (CK) reaction, which buffers ATP. This means that, even when ATP is metabolized in the brain, the decrease in its concentration is usually very small. However, phosphocreatine (PCr) and inorganic phosphate (Pi), two other metabolites connected to ATP concentration via the CK reaction, markedly vary with energy metabolism.

31Phosphorus MRS can be used to estimate the brain's energy metabolism by simultaneously measuring the concentrations of ATP, PCr and Pi. In collaboration with Naftali Raz and Jeff Stanley from Wayne State University, the project is working on establishing 31Phosphorus MRS as a technique at the Institute. 31Phosphorus MRS will allow researchers at the Center for Lifespan Psychology to chart the ranges of cerebral energy consumption from childhood to old age.

MR Phosphor-Spektroskopie | Center for Lifespan Psychology
© MPI fuer Bildungsforschung

31P spectrum from the human brain, processed using AMARES

Master's Thesis

Paul Enggruber & Felix Kreis (Physik, Technische Universität Berlin):
Development of Three-dimensional Spectrally Selective Phosphorus Magnetic Resonance Imaging for Analysing Metabolism in the Human Brain