Jacobs Development Study

A study of the Minerva Group led by Yee Lee Shing

This longitudinal study aimed to elucidate the roles of glucocorticoid and inflammation signaling in mediating the effects of stress on neural and behavioral development while assessing moderators at multiple levels, including (epi-)genetic dispositions.

The Jacobs Study investigated (German-speaking) children who started school in 2014 or 2015. The data collection has been completed and the data are currently being analyzed. Publications on the study's findings will be listed on this website as soon as they become available.


Keresztes, A., Raffington, L., Bender, A. R., Bögl, K., Heim, C., & Shing, Y. L. (2020). Hair cortisol concentrations are associated with hippocampal subregional volumes in children. Scientific Reports, 10, Article 4865. https://doi.org/10.1038/s41598-020-61131-x
Raffington, L., Falck, J., Heim, C., Mather, M., & Shing, Y. L. (2020). Effects of stress on 6- and 7-year-old children's emotional memory differs by gender. Journal of Experimental Child Psychology, 199, Article 104924. https://doi.org/10.1016/j.jecp.2020.104924
Raffington, L., Czamara, D., Mohn, J. J., Falck, J., Schmoll, V., Heim, C., Binder, E. B., & Shing, Y. L. (2019). Stable longitudinal associations of family income with children's hippocampal volume and memory persist after controlling for polygenic scores of educational attainment. Developmental Cognitive Neuroscience, 40, Article 100720. https://doi.org/10.1016/j.dcn.2019.100720
Raffington, L., Prindle, J. J., Keresztes, A., Binder, J., Heim, C., & Shing, Y. L. (2018). Blunted cortisol stress reactivity in low-income children relates to lower memory function. Psychoneuroendocrinology, 90, 110–121. https://doi.org/10.1016/j.psyneuen.2018.02.002
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