Main Focus

  • Neuroimmunosenescence
  • Neuroinflammation and brain plasticity in aging
  • Interdisciplinary gerontology
  • Immunosenescence
  • Tumour immunology

Project Participation

Berliner Aging Study II (BASE-II)
Mechanisms and Sequential Progression of Plasticity

Curriculum Vitae

2003   Award with a "Margarete-von-Wrangell-Habilitationsprogramm" grant
1997    Dr. rer. nat., Eberhard-Karls-Universität Tübingen
1994    Dipl. Biologin, Eberhard-Karls-Universität Tübingen
1986    Dipl. Biologin, Ural-State-University, Sverdlovsk

Selected Literature

    Müller, L., & Pawelec, G. (2021). The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention. In N. Musi & P. J. Hornsby (Eds.), Handbook of the biology of aging (9th ed., pp. 345–366). Academic Press.

    Pawelec, G., & Müller, L. (2021). Immunology of ageing. In M. Wasserman, D. Bakerjian, S. Linnebur, S. Brangman, & A. Mims (Eds.), Geriatric medicine. Springer Nature.

    Müller, L. and Pawelec, G. (2020). Immune compromise in the elderly. In K. E. Sullivan & E. R. Stiehm (Eds.), Stiehm's immune deficiencies (2nd ed.). Amsterdam: Elsevier.

    Di Benedetto, S. and Müller, L. (2019). Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition. In M. Mahmoudi & N. Rezaei (Eds.), Nutrition and Immunity. Springer.

    Di Benedetto, S., Müller, L., Rauskolb, S., Sendtner, M., Deutschbein, T., Pawelec, G., & Müller, V. (2019). Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women. Immunity & Ageing. doi: org/10.1186/s12979-019-0171-x

    Müller, L., Di Benedetto, S., & Pawelec, G. (2019). Human immune system in aging. In D. Gu & M. E. Dupre (Eds.), Encyclopedia of gerontology and population aging. Cham: Springer. Advance online publication. doi:10.1007/978-3-319-69892-2_68-1

    Müller, L., Di Benedetto, S., & Pawelec, G. (2019). The immune system and its dysregulation with aging. In J. R. Harris & V. I. Korolchuk (Eds.), Biochemistry and cell biology of ageing: Part II clinical science (Subcellular Biochemistry No. 91) (pp. 21-43). Singapore: Springer Nature. doi:10.1007/978-981-13-3681-2_2

    Di Benedetto, S., Gaetjen, M., & Müller, L. (2019). The modulatory effect of gender and cytomegalovirus-seropositivity on circulating inflammatory factors and cognitive performance in elderly individuals. International Journal of Molecular Sciences, 20(4):990. doi:10.3390/ijms20040990

    Pawelec, G., Müller, L., Fülöp, T., & Dunn-Walters, D. (2018). Immune system changes and immunosenescence. In J.-P. Michel, B. L. Beattie, F. C. Martin, & J. D. Walston (Eds.), Oxford textbook of geriatric medicine (3rd rev. ed., pp. 331-336). Oxford: Oxford University Press.

    Müller, L., Hamprecht, K., & Pawelec, G. (2017). The role of CMV in "immunosenescence". In V. Bueno, J. M. Lord, & T. A. Jackson (Eds.), The ageing immune system and health (pp. 53-68). Cham: Springer. doi:10.1007/978-3-319-43365-3_4

    Di Benedetto, S., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017). Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neuroscience & Biobehavioral Reviews. 75, 114-128. doi:10.1016/j.neubiorev.2017.01.044

    Müller, L., & Pawelec, G. (2016). The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention. In M. R. Kaeberlein & G. M. Martin (Eds.), The handbook of the biology of aging (8th ed., pp. 407-431). London: Academic Press.

    Müller, L., & Pawelec, G. (2015). As we age: Does slippage of quality control in the immune system lead to collateral damage? Ageing Research Reviews, 23(Part A), 116-123. doi:10.1016/j.arr.2015.01.005

    Müller, L. & Pawelec, G. (2014). Aging and immunity: Impact of behavioral intervention. Brain, Behavior, and Immunity, 39(July), 8–22. doi:10.1016/j.bbi.2013.11.015

    Müller, L., Fülöp, T., & Pawelec, G. (2013). Immunosenescence in vertebrates and invertebrates. Immunity & Ageing, 10:12. doi:10.1186/1742-4933-10-12

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