Sandra Düzel

+49 30 82406-311
duezel [at] mpib-berlin [dot] mpg [dot] de

Project participation: 

Research Interests: 

Memory, lifestyle, and healthy aging - A neurobiological approach

Age-related changes in the episodic memory network and neuromodulation affect memory and motivation. There is growing consensus that lifestyle factors such as physical exercise, cognitive and social enrichment, and nutrition not only influence motivational aspects but also show effects on the brainstructure. However, it is still largely unknown how lifestyle and neurobiological factors interact. Recent neurobiological findings lead to a more positive view of cognitive aging: physical exercise, for example, seems to induce plasticity –also in the aging brain.

Within BASE-II, I will focus on investigating the interactions between lifestyle factors, cognitive, and neurobiological variables. I will further investigate a new concept, the „subjective health horizon,“ which offers an extended theoretical perspective from the „Selection- Optimization- Compensation-Theory“ (SOC) and the „Socio-Emotional-Selectivity Model.“ This new concept integrates recent neurobiological findings linking lifestyle factors such as physical activity, future thinking, motivation, and novelty, thus leading to new implications for healthy aging. To investigate the aforementioned relationships, I will combine structural imaging methods and psychosocial parameters using VBM and ROI-based analyses, among others.

open all Curriculum Vitae

zuklappen Sandra Düzel_CV

10/2010   Dr.rer.nat. (PhD); Magna cum laude; Faculty of Science; University of Magdeburg; Germany; Dissertation: „Healthy aging and memory. The influence of neuromodlatory and psychosocial factors.“; Advisors: Prof. Münte;

10/2005- 07/2007  visiting student at the Institute of Cognitive Neuroscience at UCL; UK

12/2004 –10/2010  PhD-student “healthy aging and memory: The influence of neuromodulatory and psycholsocial factors”; Department of neuropsychology, O.v.G. University Magdeburg, Germany, Advisors: Prof. Thomas Muente; Prof. Heinze

02/2001  Diploma in Health Science; University of Applied Science Magdeburg/Stendal, Germany; Advisors: Prof. Göpel

03/1996-02/2001 Study of Health Sciences; Department of social and health studies, Magdeburg-Stendal University of Applied Sciences, Germany, Major: Health promotion and Health management

07/1995 Abitur; Gymnasium Burg, Germany

zuklappen Publications

Kolodziejczak, K., Rosada, A., Drewelies, J., Düzel, S., Eibich, P., Tegeler, C., Wagner, G. G., Beier, K. M., Ram, N., Demuth, I., Steinhagen-Thiessen, E., & Gerstorf, D. (in press). Sexual activity, sexual thoughts, and intimacy among older adults: Links with physical health and psychosocial resources for successful aging. Psychology and Aging.

Hensel, C., Becker, M., Düzel, S., Demuth, I., Norman, K., Steinhagen-Thiessen, E., Gallinat, J., Lindenberger, U., & Kühn, S. (2019). Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans. NeuroImage, 193, 139-145. doi:10.1016/j.neuroimage.2019.03.005
Full text

Kozik, P., Drewelies, J., Düzel, S., Demuth, I., Steinhagen-Thiessen, E., Gerstorf, D., & Hoppmann, C. A. (2019). Future time perspective: Dimensions of opportunities, life, and time are differentially associated with physical health, cognitive functioning, and well-being in old age. Aging and Mental Health. Advance online publication. doi:10.1080/13607863.2019.1594159
Full text

Düzel, S., Buchmann, N., Drewelies, J., Gerstorf, D., Lindenberger, U., Steinhagen-Thiessen, E., Norman, K., & Demuth, I. (2018). Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function. PLoS ONE, 13(12):e0208231. doi:10.1371/journal.pone.0208231

Düzel, S., Drewelies, J., Gerstorf, D., Demuth, I., Kühn, S., & Lindenberger, U. (2018). Facets of subjective health horizons are differentially linked to brain volume. GeroPsych, 31, 127-136. doi:10.1024/1662-9647/a000191
Full text

Düzel, S., & Gerstorf, D. (Eds.). (2018). The (domain-differentiated) nature of future time perspective and its antecedents, correlates, and consequences [Special issue]. GeroPsych. 31(3).

Düzel, S., & Gerstorf, D. (2018). The (domain-differentiated) nature of future time perspective: Its antecedents, correlates, and consequences. Editorial. GeroPsych, 31, 101. doi:10.1024/1662-9647/a000195
Full text

Kühn, S., Düzel, S., Drewelies, J., Gerstorf, D., Lindenberger, U., & Gallinat, J. (2018). Psychological and neural correlates of embitterment in old age. Psychological Trauma: Theory, Research, Practice, and Policy, 10, 51-57. doi:10.1037/tra0000287
Full text

Notthoff, N., Drewelies, J., Kazanecka, P., Steinhagen-Thiessen, E., Norman, K., Düzel, S., Daumer, M., Lindenberger, U., Demuth, I., & Gerstorf, D. (2018). Feeling older, walking slower - but only if someone's watching: Subjective age is associated with walking speed in the laboratory, but not in real life. European Journal of Ageing, 15, 425-433. doi:10.1007/s10433-017-0450-3
Full text

Walhovd, K. B., Fjell, A. M., Westerhausen, R., Nyberg, L., Ebmeier, K. P., Lindenberger, U., Bartrés-Faz, D., Baaré, W. F. C., Siebner, H. R., Henson, R., Drevon, C. A., Strømstad Knudsen, G. P., Budin Ljøsne, I., Penninx, B. W. J. H., Ghisletta, P., Rogeberg, O., Tyler, L., Bertram, L., & Lifebrain Consortium (2018). Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). European Psychiatry, 50, 47-56. doi:10.1016/j.eurpsy.2017.12.006
Full text

Delius, J. A. M., Düzel, S., Gerstorf, D., & Lindenberger, U. (2017). Berlin Aging Studies (BASE and BASE-II). In N. A. Pachana (Ed.), Encyclopedia of geropsychology (pp. 386-395). New York: Springer.

Di Benedetto, S., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017). Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neuroscience & Biobehavioral Reviews, 75, 114-128. doi:10.1016/j.neubiorev.2017.01.044
Full text

Kühn, S., Düzel, S., Colzato, L., Norman, K., Gallinat, J., Brandmaier, A. M., Lindenberger, U., & Widaman, K. F. (2017). Food for thought: Association between dietary tyrosine and cognitive performance in younger and older adults. Psychological Research. Advance online publication. doi:10.1007/s00426-017-0957-4
Full text

Kühn, S., Düzel, S., Eibich, P., Krekel, C., Wüstemann, H., Kolbe, J., Mårtensson, J., Goebel, J., Gallinat, J., Wagner, G. G., & Lindenberger, U. (2017). In search of features that constitute an "enriched environment" in humans: Associations between geographical properties and brain structure. Scientific Reports, 7:11920. doi:10.1038/s41598-017-12046-7
Full text

Düzel, S., Voelkle, M. C., Düzel, E., Gerstorf, D., Drewelies, J., Steinhagen-Thiessen, E., Demuth, I., & Lindenberger, U. (2016). The Subjective Health Horizon Questionnaire (SHH-Q): Assessing the future time perspectives for facets of an active lifestyle. Gerontology, 62, 345-353. doi:10.1159/000441493
Full text

Hülür, G., Drewelies, J., Eibich, P., Düzel, S., Demuth, I., Ghisletta, P., Steinhagen-Thiessen, E., Wagner, G. G., Lindenberger, U., & Gerstorf, D. (2016). Cohort differences in psychosocial function over 20 years: Current older adults feel less lonely and less dependent on external circumstances. Gerontology, 62, 354-361. doi:10.1159/000438991
Full text

Kroh, M., Lüdtke, D., Düzel, S., & Winter, F. (2016). Response error in a web survey and a mailed questionnaire: The role of cognitive functioning (SOEPpapers on Multidisciplinary Panel Data Research No. 888). Berlin: DIW.
Full text

Maass, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövdén, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., Ahrens, D., Heinze, H.-J., Müller, N. G., Lessmann, V., Sendtner, M., & Düzel, E. (2016). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage, 131, 142-154. doi:10.1016/j.neuroimage.2015.10.084
Full text

Delius, J. A. M., Düzel, S., Gerstorf, D., & Lindenberger, U. (2015). Berlin Aging Studies (BASE and BASE-II). In N. A. Pachana (Ed.), Encyclopedia of geropsychology [Online version]. New York: Springer. doi:10.1007/978-981-287-080-3_44-1
Full text

Gerstorf, D., Hülür, G., Drewelies, J., Eibich, P., Düzel, S., Demuth, I., Ghisletta, P., Steinhagen-Thiessen, E., Wagner, G. G., & Lindenberger, U. (2015). Secular changes in late-life cognition and well-being: Towards a long bright future with a short brisk ending? Psychology and Aging, 30, 301-310. doi:10.1037/pag0000016
Full text

Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., Ahrens, D., Heinze, H.-J., Müller, N., & Düzel, E. (2015). Vascular hippocampal plasticity after aerobic exercise in older adults. Molecular Psychiatry, 20, 585-593. doi:10.1038/mp.2014.114
Full text

Bertram, L., Böckenhoff, A., Demuth, I., Düzel, S., Eckardt, R., Li, S.-C., Lindenberger, U., Pawelec, G., Siedler, T., Wagner, G. G., & Steinhagen-Thiessen, E. (2014). Cohort profile: The Berlin Aging Study II (BASE-II). International Journal of Epidemiology, 43, 703-712. doi:10.1093/ije/dyt018
Full text

Schröder, J., Ansaloni, S., Schilling, M., Liu, T., Radke, J., Jädicke, M., Schjeide, B.-M. M., Mashychev, A., Tegeler, C., Radbruch, H., Papenberg, G., Düzel, S., Demuth, I., Bucholtz, N., Lindenberger, U., Li, S.-C., Steinhagen-Thiessen, E., Lill, C. M., & Bertram, L. (2014). MicroRNA-138 is a potential regulator of memory performance in humans. Frontiers in Human Neuroscience, 8:501. doi:10.3389/fnhum.2014.00501
Full text

Düzel, S., Münte, T. F., Lindenberger, U., Bunzeck, N., Schütze, H., Heinze, H.-J., & Düzel, E. (2010). Basal forebrain integrity and cognitive memory profile in healthy aging. Brain Research, 1308, 124-136. doi:10.1016/j.brainres.2009.10.048
Full text

Düzel, S., Schütze, H., Stallforth, S., Kaufmann, J., Bodammer, N. C., Bunzeck, N., Münte, T. F., Lindenberger, U., Heinze, H.-J., & Düzel, E. (2008). A close relationship between verbal memory and SN/VTA integrity in young and older adults. Neuropsychologia, 46, 3042-3052. doi:10.1016/j.neuropsychologia.2008.06.001
Full text

Helm, N., & Düzel, S. (2010). Lebensstilabhängige Gesundheitsfaktoren, kognitives Altern und Demenz. Klinische Neurophysiologie, 41, 116–124. doi: 10.1055/s-0030-1252041
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010). NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): Implications for healthy aging. Neuroscience & Biobehavioral Reviews, 34, 660–669. doi: 10.1016/j.neubiorev.2009.08.006
Bunzeck, N., Schütze, H., Stallforth, S., Kaufmann, J., Düzel, S., Heinze, H. J., & Düzel, E. (2007). Mesolimbic novelty processing in older adults. Cerebral Cortex, 17, 2940–2498. doi: 10.1093/cercor/bhm020
Full text <http://cercor.oxfordjournals.org/content/17/12/2940.full?sid=6888ed7f-2cbe-4ae9-a31a-54a5ab4db583>