Sandra Düzel

+49 30 82406-311
duezel [at] mpib-berlin [dot] mpg [dot] de

Project participation: 

Research Interests: 

Memory, lifestyle, and healthy aging - A neurobiological approach

Age-related changes in the episodic memory network and neuromodulation affect memory and motivation. There is growing consensus that lifestyle factors such as physical exercise, cognitive and social enrichment, and nutrition not only influence motivational aspects but also show effects on the brainstructure. However, it is still largely unknown how lifestyle and neurobiological factors interact. Recent neurobiological findings lead to a more positive view of cognitive aging: physical exercise, for example, seems to induce plasticity –also in the aging brain.

Within BASE-II, I will focus on investigating the interactions between lifestyle factors, cognitive, and neurobiological variables. I will further investigate a new concept, the „subjective health horizon,“ which offers an extended theoretical perspective from the „Selection- Optimization- Compensation-Theory“ (SOC) and the „Socio-Emotional-Selectivity Model.“ This new concept integrates recent neurobiological findings linking lifestyle factors such as physical activity, future thinking, motivation, and novelty, thus leading to new implications for healthy aging. To investigate the aforementioned relationships, I will combine structural imaging methods and psychosocial parameters using VBM and ROI-based analyses, among others.

open all Curriculum Vitae

zuklappen Sandra Düzel_CV

10/2010   Dr.rer.nat. (PhD); Magna cum laude; Faculty of Science; University of Magdeburg; Germany; Dissertation: „Healthy aging and memory. The influence of neuromodlatory and psychosocial factors.“; Advisors: Prof. Münte;

10/2005- 07/2007  visiting student at the Institute of Cognitive Neuroscience at UCL; UK

12/2004 –10/2010  PhD-student “healthy aging and memory: The influence of neuromodulatory and psycholsocial factors”; Department of neuropsychology, O.v.G. University Magdeburg, Germany, Advisors: Prof. Thomas Muente; Prof. Heinze

02/2001  Diploma in Health Science; University of Applied Science Magdeburg/Stendal, Germany; Advisors: Prof. Göpel

03/1996-02/2001 Study of Health Sciences; Department of social and health studies, Magdeburg-Stendal University of Applied Sciences, Germany, Major: Health promotion and Health management

07/1995 Abitur; Gymnasium Burg, Germany

zuklappen Publications

Di Benedetto, S., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017). Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neuroscience & Biobehavioral Reviews, 75, 114-128. doi:10.1016/j.neubiorev.2017.01.044
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Düzel, S., Voelkle, M. C., Düzel, E., Gerstorf, D., Drewelies, J., Steinhagen-Thiessen, E., Demuth, I., & Lindenberger, U. (2016). The Subjective Health Horizon Questionnaire (SHH-Q): Assessing the future time perspectives for facets of an active lifestyle. Gerontology, 62, 345-353. doi:10.1159/000441493
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Hülür, G., Drewelies, J., Eibich, P., Düzel, S., Demuth, I., Ghisletta, P., Steinhagen-Thiessen, E., Wagner, G. G., Lindenberger, U., & Gerstorf, D. (2016). Cohort differences in psychosocial function over 20 years: Current older adults feel less lonely and less dependent on external circumstances. Gerontology, 62, 354-361. doi:10.1159/000438991
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Kroh, M., Lüdtke, D., Düzel, S., & Winter, F. (2016). Response error in a web survey and a mailed questionnaire: The role of cognitive functioning (SOEPapers on Multidisciplinary Panel Data Research No. 888). Berlin: DIW.
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Maass, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövdén, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., Ahrens, D., Heinze, H.-J., Müller, N. G., Lessmann, V., Sendtner, M., & Düzel, E. (2016). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage, 131, 142-154. doi:10.1016/j.neuroimage.2015.10.084
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Delius, J. A. M., Düzel, S., Gerstorf, D., & Lindenberger, U. (2015). Berlin Aging Studies (BASE and BASE-II). In N. A. Pachana (Ed.), Encyclopedia of geropsychology. New York: Springer. doi:10.1007/978-981-287-080-3_44-1
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Gerstorf, D., Hülür, G., Drewelies, J., Eibich, P., Düzel, S., Demuth, I., Ghisletta, P., Steinhagen-Thiessen, E., Wagner, G. G., & Lindenberger, U. (2015). Secular changes in late-life cognition and well-being: Towards a long bright future with a short brisk ending? Psychology and Aging, 30, 301-310. doi:10.1037/pag0000016
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Maass, A., Düzel, S., Goerke, M., Becke, A., Sobieray, U., Neumann, K., Lövden, M., Lindenberger, U., Bäckman, L., Braun-Dullaeus, R., Ahrens, D., Heinze, H.-J., Müller, N., & Düzel, E. (2015). Vascular hippocampal plasticity after aerobic exercise in older adults. Molecular Psychiatry, 20, 585-593. doi:10.1038/mp.2014.114
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Bertram, L., Böckenhoff, A., Demuth, I., Düzel, S., Eckardt, R., Li, S.-C., Lindenberger, U., Pawelec, G., Siedler, T., Wagner, G. G., & Steinhagen-Thiessen, E. (2014). Cohort profile: The Berlin Aging Study II (BASE-II). International Journal of Epidemiology, 43, 703-712. doi:10.1093/ije/dyt018
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Schröder, J., Ansaloni, S., Schilling, M., Liu, T., Radke, J., Jädicke, M., Schjeide, B.-M. M., Mashychev, A., Tegeler, C., Radbruch, H., Papenberg, G., Düzel, S., Demuth, I., Bucholtz, N., Lindenberger, U., Li, S.-C., Steinhagen-Thiessen, E., Lill, C. M., & Bertram, L. (2014). MicroRNA-138 is a potential regulator of memory performance in humans. Frontiers in Human Neuroscience, 8:501. doi:10.3389/fnhum.2014.00501
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Düzel, S., Münte, T. F., Lindenberger, U., Bunzeck, N., Schütze, H., Heinze, H.-J., & Düzel, E. (2010). Basal forebrain integrity and cognitive memory profile in healthy aging. Brain Research, 1308, 124-136. doi:10.1016/j.brainres.2009.10.048
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Düzel, S., Schütze, H., Stallforth, S., Kaufmann, J., Bodammer, N. C., Bunzeck, N., Münte, T. F., Lindenberger, U., Heinze, H.-J., & Düzel, E. (2008). A close relationship between verbal memory and SN/VTA integrity in young and older adults. Neuropsychologia, 46, 3042-3052. doi:10.1016/j.neuropsychologia.2008.06.001
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Helm, N., & Düzel, S. (2010). Lebensstilabhängige Gesundheitsfaktoren, kognitives Altern und Demenz. Klinische Neurophysiologie, 41, 116–124. doi: 10.1055/s-0030-1252041
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010). NOvelty-related motivation of anticipation and exploration by dopamine (NOMAD): Implications for healthy aging. Neuroscience & Biobehavioral Reviews, 34, 660–669. doi: 10.1016/j.neubiorev.2009.08.006
Bunzeck, N., Schütze, H., Stallforth, S., Kaufmann, J., Düzel, S., Heinze, H. J., & Düzel, E. (2007). Mesolimbic novelty processing in older adults. Cerebral Cortex, 17, 2940–2498. doi: 10.1093/cercor/bhm020
Full text <http://cercor.oxfordjournals.org/content/17/12/2940.full?sid=6888ed7f-2cbe-4ae9-a31a-54a5ab4db583>