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Berlin Aging Study II (BASE-II)

One of the most salient aspects of aging is its heterogeneity. Some individuals maintain their health and preserve their cognitive abilities into advanced ages, whereas others show precipitous and early decline. To understand the mechanisms that produce this diversity of outcomes, we need to follow the trajectories of aging individuals over time. With this goal in mind, researchers from Berlin and Tübingen initiated the Berlin Aging Study II (Bertram et al., 2014). Like BASE, BASE-II was set up as a multidisciplinary and multi-institutional longitudinal study that captures a wide range of different functional domains. Geriatrics and internal medicine as well as immunology, psychology, genetics, sociology, and economics are among the disciplines involved. The study received financial support from the Federal Ministry of Education and Research. The recruitment of the BASE-II cohort, which was completed in 2013, resulted in a consolidated baseline sample of 1,600 older adults aged 60 to 80 years and of 600 younger adults aged 20 to 35 years (Bertram et al., 2014). Data from this baseline sample can be linked to the German Socio-Economic Panel Study (SOEP), a longitudinal panel survey that is representative of the German population, to estimate sample selectivity. See BASE-II in SOEP.

Testing at the Center for Lifespan Psychology

Cognitive Battery of BASE-II
© MPI fuer Bildungsforschung

After extensive piloting, a comprehensive battery of cognitive tests and a psychological questionnaire were added to the baseline protocol in March 2013. The cognitive test battery is distributed across two testing sessions. It includes various facets of episodic memory as well as measures of working memory, cognitive control, fluid intelligence, reading skills, and decision making. It also includes a newly developed measure of subjective health, the subjective health horizon (SHH), to assess participants’ motivation to engage in explorative and novel activities (Düzel et al., 2016). The psychological questionnaire contains measures of self-reported health, well-being, personality, stress, coping, and of attitudes toward aging.

Steering Group

Denis Gerstorf (Speaker)

Humboldt-Universität zu Berlin & German Institute for Economic Research

Lars Bertram University of Lübeck
Ulman Lindenberger

Max Planck Institute for Human Development

Graham Pawelec University of Tübingen
Elisabeth Steinhagen-Thiessen Charité – Universitätsmedizin Berlin
Gert G. Wagner German Institute for Economic Research & Max Planck Institute for Human Development

Coordination

 
Katrin Schaar Max Planck Institute for Human Development

Recent Publications

Hensel, C., Becker, M., Duezel, S., Demuth, I., Norman, K., Steinhagen-Thiessen, E., ... Kühn, S. (2019). Influence of nutritional tyrosine on cognition and functional connectivity in healthy old humans. NeuroImage, 193, 139–145. https://doi.org/10.1016/j.neuroimage.2019.03.005

Kozik, P., Drewelies, J., Düzel, S., Demuth, I., Steinhagen-Thiessen, E., Gerstorf, D., & Hoppmann, C. A. (2019). Future time perspective: Dimensions of opportunities, life, and time are differentially associated with physical health, cognitive functioning, and well-being in old age. Aging & Mental Health. Advance online publication. https://doi.org/10.1080/13607863.2019.1594159

Davies, G., Lam, M., Harris, S. E., Trampush, J., Luciano, M., ... Lindenberger, U., ... Deary, I. J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 9: 2098. https://doi.org/10.1038/s41467-018-04362-x

Düzel, S., Buchmann, N., Drewelies, J., Gerstorf, D., Lindenberger, U., Steinhagen-Thiessen, E., ... Demuth, I. (2018). Validation of a single factor representing the indicators of metabolic syndrome as a continuous measure of metabolic load and its association with health and cognitive function. PLoS ONE, 13(12): e0208231. https://doi.org/10.1371/journal.pone.0208231

Düzel, S., Drewelies, J., Kühn, S., Gerstorf, D., & Lindenberger, U. (2018). Facets of subjective health horizons are differentially linked to brain volume. GeroPsych, 31, 127–136. https://doi.org/10.1024/1662-9647/a000191

Düzel, S., & Gerstorf, D. (2018). The (domain-differentiated) nature of future time perspective and its antecedents, correlates, and consequences [Editorial]. GeroPsych, 31, 101. https://doi.org/10.1024/1662-9647/a000195

Düzel, S., & Gerstorf, D. (Eds.). (2018). Special issue: Future time perspectives. GeroPsych, 31(3).

König, M., Drewelies, J., Norman, K., Spira, D., ... Lindenberger, U., ... Demuth, I. (2018). Historical trends in modifiable indicators of cardiovascular health and self-rated health among older adults: Cohort differences over 20 years between the Berlin Aging Study (BASE) and the Berlin Aging Study II (BASE-II). PLoS ONE, 13(1): e0191699. https://doi.org/10.1371/journal.pone.0191699

Notthoff, N., Drewelies, J., ... Steinhagen-Thiessen, E., Norman, K., Düzel, S., ... Lindenberger, U., ... Gerstorf, D. (2018). Feeling older, walking slower—but only if someone's watching: Subjective age is associated with walking speed in the laboratory, but not in real life. European Journal of Ageing, 15, 425–433. https://doi.org/10.1007/s10433-017-0450-3

Walhovd, K. B., Fjell, A. M., Westerhausen, R., Nyberg, L., Ebmeier, K. P., Lindenberger, U., ... for Lifebrain Consortium. (2018). Healthy minds from 0–100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). European Psychiatry, 50, 47–56. https://doi.org/10.1016/j.eurpsy.2017.10.006

Kühn, S., Düzel, S., Colzato, L., Norman, K., ... Brandmaier, A. M., Lindenberger, U., & Widaman, K. F. (2017). Food for thought: Association between dietary tyrosine and cognitive performance in younger and older adults. Psychological Research. Advance online publication. https://doi.org/10.1007/s00426-017-0957-4

See also the publication list on the BASE-II website

Team

Sandra Düzel
Ulman Lindenberger
Gert G. Wagner

Mara Mather (Adjunct Researcher, Max Planck Sabbatical Award)

Caroline Beese
Ylva Köhncke (postdocs)

Katrin Schaar (coordination)

Kirsten Becker (research assistant)
Martin Becker (database management)

For external cooperation partners: see overview of Steering Group to the left

Lifebrain

Liefebrain Logo

BASE and BASE-II are participating in Lifebrain, an EU funded project. It integrates data from 6000 participants in 11 European neuroimaging studies carried out in 7 countries.

Website: www.lifebrain.uio.no

Walhovd, K. B., Fjell, A. M., Westerhausen, R., Nyberg, L., Ebmeier, K. P., Lindenberger, U., ... for Lifebrain Consortium. (2018). Healthy minds from 0–100 years: Optimising the use of European brain imaging cohorts ("Lifebrain"). European Psychiatry, 50, 47–56. https://doi.org/ 10.1016/j.eurpsy.2017.12.006

Key References

Bertram, L., Böckenhoff, A., Demuth, I., Düzel, S., Eckardt, R., Li, S.-C., Lindenberger, U., Pawelec, G., Siedler, T., Wagner, G. G., & Steinhagen-Thiessen, E. (2014). Cohort profile: The Berlin Aging Study II (BASE-II). International Journal of Epidemiology, 43, 703–712. doi: 10.1093/ije/ dyt018

Delius, J. A. M., Düzel, S., Gerstorf, D., & Lindenberger, U. (2017). Berlin Aging Studies (BASE and BASE-II). In N. A. Pachana (Ed.), Encyclopedia of geropsychology (pp. 386–395). New York: Springer. doi: 10.1007/978-981-287-080-3_44-1

Gerstorf, D., Bertram, L., Lindenberger, U., Pawelec, G., Wagner, G. G., & Steinhagen-­Thiessen, E. (Eds.). (2016). The Berlin Aging Study II: An overview [Special section]. Gerontology, 62, 311–370.

See also publication list on the BASE-II website

BASE-II Website

Logo BASE II | Berli Aging Study II

BERLIN Aging Study II (BASE-II)

www.base2.mpg.de